Abstract
Neutron small-angle scattering of fibrinogen in various H 2O 2H 2O mixtures is strictly proportional to the square of the contrast at a resolution of less than 15 Å. Therefore, the excess scattering density with respect to the solvent is positive everywhere. The maximum scattering density is only a quarter of that encountered with globular proteins. It is not so low that fibrinogen could be regarded as a statistical coil. The shape is resolved in terms of multipoles. A stepwise increase in the resolution is achieved by taking into account an increasing number of multipoles; on addition of a dipolar term to the spherical average a cup-shaped model results. A still better description is obtained if the quadrupolar term is derived from the scattering curve. The superposition of the first three multipoles leads to a banana-shaped fibrinogen model. This result, from the analysis of the scattering pattern in terms of multipoles, is compared with other physicochemical and biochemical properties of fibrinogen.
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