A Neuronal Network Model with Plasticity for Tinnitus Management by Sound Therapy

Abstract

A perception of hearing sounds in the ear or head without any external source is referred to as tinnitus. There are many therapeutic approaches for tinnitus and sound therapy techniques for its treatment has been proposed. In order to investigate mechanisms of tinnitus generation and the clinical effects of sound therapy from the viewpoint of neural engineering, we have proposed a computational model using a neural oscillator. In the present paper, we propose another model that is composed of model neurons described by simplified Hodg-kin-Huxley equations. By computer simulation it was detected that this model also has a bistable state, i.e., a stable oscillatory state and a stable equilibrium (non-oscillatory) state coexist at a certain parameter region. It was also noticed that the oscillation can be inhibited by supplying constant or pulse train stimulus, which is hypothesized as an afferent signal that is employed as an acoustical stimulus for tinnitus treatment. By hypothesizing that the oscillation and the equilibrium correspond to generation and inhibition of tinnitus, respectively, these phenomena could explain the fact that the habituated human auditory system temporarily halts perception of tinnitus following sound therapy.