Abstract
This article reports a critical role for the vagal gut-to-brain axis in motivation and reward amongst the sensory cells of the right vagal nerve. Optogenetic stimulation of the mouse vagal gut-to-brain axis produced reward behaviors. Stimulation of gut-innervating vagal sensory neurons recapped the hallmark effects of stimulating the right, but not left, vagal sensory ganglion, induced dopamine release from the Substantia nigra, sustained self-stimulation behavior, and conditioned both flavour and place preferences.
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