Abstract
Objective Yifei Sanjie Formula (YFSJF) is an effective formula on pulmonary fibrosis (PF), which has been used in clinic for more than 30 years. In order to investigate the molecular mechanism of YFSJF in treating PF, network pharmacology was used to predict the cooperative ingredients and associated pathways. Methods Firstly, we collected potential active ingredients of YFSJF by TCMSP databases. Secondly, we obtained PF-associated targets through OMIM and Genecards database. Finally, metascape was applied for the analysis of GO terms and KEGG pathways. Results We screened out 76 potential active ingredients and 98 associated proteins. A total of 5715 items were obtained by GO enrichment analysis (P < 0.05), including 4632 biological processes, 444 cellular components, and 639 molecular functions. A total of 143 related KEGG pathways were enriched (P < 0.05), including IL-17 signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, calcium signaling pathway, TH17 cell differentiation, HIF-1 signaling pathway, and PI3K-Akt signaling pathway. Conclusion YFSJF can interfere with immune and inflammatory response through multiple targets and pathways, which has a certain role in the treatment of PF. This study lays a foundation for future experimental research.
Highlights
Pulmonary fibrosis (PF) is a common and irreversible pathological outcome of many chronic lung diseases, which is characterized by progressive alveolar epithelial injury and abnormal repair
Yifei Sanjie Formula (YFSJF) is an effective formula in treating pulmonary fibrosis (PF), which is authorized by professor Qingshen Li, a famous physician of traditional Chinese medicine in Yunnan Province. e formula is based on Yupingfeng formula, which is composed of Sangbaipi (Mori Cortex), Zhebeimu (Fritillariae unbrgii Bulbus), Jiezi (Sinapis Semen), E’zhu (Curcumae Rhizoma), and Sanqi
Among them 20 ingredients were from Hedysarum Multijugum Maxim (HMM), 11 from Saposhnikoviae Radix (SR), 7 from Atractylodes Macrocephala Koidz (AMK), 7 from Fritillariae unbrgii Bulbus (FTB), 3 from Sinapis Semen (SS), 24 from Mori Cortex (MC), 8 from Panax Notoginseng (Burk.) F
Summary
Pulmonary fibrosis (PF) is a common and irreversible pathological outcome of many chronic lung diseases, which is characterized by progressive alveolar epithelial injury and abnormal repair. The incidence rate and mortality rate of PF are increasing [1]. It is reported that the annual incidence rate of the disease is 4.6∼16.3 per 100,000 and the prevalence rate is 13∼20 per 100,000 [2]. E main clinical treatment can be made with glucocorticoids, immunosuppressants, antioxidants, and biological agents [3]. These drugs cannot effectively reverse the development of PF and bring multiple side effects to some extent. E formula is based on Yupingfeng formula, which is composed of Sangbaipi (Mori Cortex), Zhebeimu (Fritillariae unbrgii Bulbus), Jiezi (Sinapis Semen), E’zhu (Curcumae Rhizoma), and Sanqi Yifei Sanjie Formula (YFSJF) is an effective formula in treating PF, which is authorized by professor Qingshen Li, a famous physician of traditional Chinese medicine in Yunnan Province. e formula is based on Yupingfeng formula, which is composed of Sangbaipi (Mori Cortex), Zhebeimu (Fritillariae unbrgii Bulbus), Jiezi (Sinapis Semen), E’zhu (Curcumae Rhizoma), and Sanqi
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
