Abstract
A decade ago, four independent groups reported the unanticipated and still surprising result that the bending modulus κ of bilayers of 1,2-dioleoyl- sn -glycero-3-phosphocholine (DOPC), unlike other standard lipids, does not increase with addition of cholesterol. This was shown from tube pulling (1, 2) shape analysis (SA) and electro-deformation (ED) of giant vesicles (3), and X-ray diffuse scattering (XDS) fluctuations in bilayer stacks (4). However, a recent PNAS paper (5) based on neutron spin echo (NSE) and NMR relaxation (NMRR) claims that the bending modulus of DOPC increases threefold for cholesterol mole fractions of 50%. Thus, it would appear that this is a controversial topic for understanding membrane mechanics. This controversy is needless because NSE and NMRR measure something different from … [↵][1]1To whom correspondence may be addressed. Email: nagle{at}cmu.edu. [1]: #xref-corresp-1-1
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