Abstract
A Need to Study the Immune Status of Frail Older Adults
Highlights
The frail older adult subpopulation, which is growing at a rapid rate, contributes significantly to the increasing global healthcare cost [1]
T cell immunity was based on phytohemagglutinin (PHA)induced proliferation and production of immunosuppressive interleukin (IL)-10 and immunoenhancing IL12
The demonstration that reduced immunity in older adults is correlated with chronic disease burden, but not with chronologic age, suggests that chronic disease burden markedly enhances the reduction in immunity of older adults caused by biologic aging
Summary
Steven C Castle*1, Koichi Uyemura, Tamas Fulop, Katsuiku Hirokawa and Takashi Makinodan. Chronic infections, increased levels of inflammatory mediators, disease progression and frailty have a very complex association, and, an unclear temporal relationship At this stage of progress, it would be appropriate and timely, to study the immune status of frail older adults using an instrument, such as the CIRS, to categorize frail older adults according to specific chronic disease and disease burden. The compromised immune status of frail older adults could be boosted to that of healthy older adults, thereby improving their innate and adaptive immunologic defense mechanisms to infections and response to vaccination This should significantly increase their resistance to infectious and other immunocompromised-related diseases, possibly slow the progression of chronic diseases, and, contribute to the goal of reducing the global healthcare cost. J Gerontol Series A Biol Med Sci 2005, 60:556-65
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