Abstract
Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu7.2S4/5MoS2 composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu7.2S4/5MoS2 exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal–chemodynamic–photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu7.2S4/5MoS2 shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu7.2S4/5MoS2 composite nanoflowers as photo/H2O2-responsive therapeutic agents against tumors.
Highlights
The mortality rate of cancer is expected to increase to 12 million by 2030, which increases the global concern about the effects of therapy (Cleary et al, 2014)
CSMS-PEG CNFs were synthesized using a one-pot bottom-up approach using a solvothermal method in which transition metal precursors and thioacetamide react in the presence of deionized water and PEG at 200°C for 24 h
The lattice fringes and interface of the multilayered MoS2 and Cu7.2S4 could be observed in the high-resolution TEM images (Figure 1H), indicating the crystallinity of the CSMS-PEG CNF heterostructure
Summary
The mortality rate of cancer is expected to increase to 12 million by 2030, which increases the global concern about the effects of therapy (Cleary et al, 2014). Effective cancer treatments to increase patient survival are urgently required. Radiotherapy (RT), chemotherapy, and high intensity focused ultrasound (HIFU) treatments (Chen et al, 2019; Khezri et al, 2019; Dubinsky et al, 2020) are the main clinical therapy approaches used to kill tumor cells and prolong the lives of patients. Photothermal therapy (PTT), with the advantages of high targeted location and minimal invasiveness, has received much attention in recent years (Jonathan and Yu-Chie, 2013). The unique physiochemical properties of inorganic nanosystems, including a tunable optical bandgap, Light-Triggered Therapy and Imaging controllable composition content, and desirable biocompatibility, provide excellent theranostic performances in oncological applications (Yang et al, 2018)
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