A Nationwide Antenatal Human T-Cell Leukemia Virus Type-1 Antibody Screening in Japan.

Kazuo Itabashi,Yasuhito Nerome,Tokuo Miyazawa,Akihiko Sekizawa,Toshiki Watanabe,Kaoru Uchimaru,Hiroyuki Moriuchi,Shigeru Saito,Akifumi Tokita

doi:10.3389/fmicb.2020.00595

Abstract

Japan has been running a nationwide antenatal human T-cell leukemia virus type-1 (HTLV-1) antibody screening program since 2010 for the prevention of HTLV-1 mother-to-child transmission. As part of the program, pregnant women are invited to take an HTLV-1 antibody screening test, usually within the first 30 weeks of gestation, during regular pregnancy checkups. Pregnant women tested positive on the antibody screening test undergo a confirmatory test, either western blotting or line immunoassay. In indeterminate case, polymerase chain reaction (PCR) is used as a final test to diagnose infection. Pregnant women tested positive on a confirmatory or PCR test are identified as HTLV-1 carriers. As breastfeeding is a predominant route of postnatal HTLV-1 mother-to-child transmission, exclusive formula feeding is widely used as a postnatal preventive measure. Although there is insufficient evidence that short-term breastfeeding during ≤3 months does not increase the risk of mother-to-child transmission compared to exclusive formula feeding, this feeding method is considered if the mother is eager to breastfeed her child. However, it is important that mothers and family members fully understand that there is an increase in the risk of mother-to-child transmission when breastfeeding would be prolonged. As there are only a few clinical studies on the protective effect of frozen-thawed breastmilk feeding on mother-to-child transmission of HTLV-1, there is little evidence to recommend this feeding method. Further study on the protective effects of these feeding methods are needed. It is assumed that the risk of anxiety or depression may increase in the mothers who selected exclusive formula feeding or short-term breastfeeding. Thus, an adequate support and counseling for these mothers should be provided. In addition to raising public awareness of HTLV-1 infection, epidemiological data from the nationwide program needs to be collected and analyzed. In most cases, infected children are asymptomatic, and it is necessary to clarify how these children should be followed medically.

Highlights

While the majority of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals remain asymptomatic, the two well-recognized disease associations adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) are caused by the virus
Numerous studies have demonstrated that mother-to-child transmission (MTCT) through breastfeeding is the predominant route of HTLV-1 infection (Hino et al, 1987; Murphy et al, 1989; Hino, 2011), while HAM/TSP develops in both populations infected via vertical and horizontal routes (Bartholomew et al, 1998)
Evaluation of Effect of Mother Screening on MTCT Prevention. It remains unknown whether the introduction of the screening program in Japan has contributed to a reduction in MTCT incidence at present

Summary

Introduction

While the majority of HTLV-1-infected individuals remain asymptomatic, the two well-recognized disease associations ATL and HAM/TSP are caused by the virus. HTLV-1 carriers are estimated to have a lifetime risk of 2–7% for the development of ATL (Iwanaga et al, 2012) and 0.25–3.8% for HAM/TSP (Yamano and Sato, 2012). Both these diseases exhibit serious clinical manifestations, and the associated prognosis remains poor despite therapeutic efforts (Katsuya et al, 2015; Willems et al, 2017). There are no effective measures to prevent antenatal infection, but avoiding or restricting breastfeeding is expected to reduce the number of postnatal infections via MTCT. Non-endemic and endemic countries may have different views on the need to introduce a nationwide screening program, but in countries or areas where HTLV-1 is endemic, antenatal screening is likely to contribute to a reduction in the burden of associated diseases (Ribeiro et al, 2012; Rosadas et al, 2018)

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