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Abstract
The Cardiovascular Health Study (CHS) was funded by the National Heart, Lung, and Blood Institute in 1989 to assess risk factors for myocardial infarction, stroke, and other cardiovascular diseases. Participants aged 65 years and older were recruited from random samples of Medicare eligibility lists in four communities: Sacramento County, California; Washington County, Maryland; Forsyth County, North Carolina; and Pittsburgh, Pennsylvania. MRI scans were performed at two times during the study, between 1991–1994 and between 1997–1999. The examinations included sagittal T1-weighted, axial dual echo proton density and T2-weighted scans, and axial T1-weighted scans at 5-mm intervals and with no interslice gaps. The patients who underwent a second set of scans also received a 3D axial spoiled-gradient echo scan at 1.5-mm intervals, capable of high-quality volumetry. There were 3660 participants who had an MRI during the initial evaluation period and 2317 at the second evaluation, including 2116 participants who had scans at both times. Thus the database includes a total of 5977 scans on 3861 participants. The investigators of the Cardiovascular Health Study invite neuroscience researchers to utilize the MRI images and summary data collected from the participants in the CHS study.
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