Abstract
Introduction. Clostridium difficile has been identified as the leading cause of antibiotic therapy-associated diarrhea and colitis, which has evolved from sporadic complications of antimicrobial therapy to severe, sometimes fatal events that have eventually become an endemic life-threatening issue among hospitalized and immunosuppressed patients worldwide. 
 Material and methods. The analysis of the relevant bibliographic sources retrieved from the PubMed, Google Scholar, and other platforms was carried out. All the articles related to these research objectives were selected, followed by exclusion of articles focused on clinics and diagnosis. The study included 43 content-based relevant articles. This present article reveals the evolving epidemiology of C. difficile infection (CDI). 
 Results. Clostridium difficile is a sporulated bacterium responsible for infectious diarrhea and pseudomembranous colitis, showing high morbidity and mortality rates among patients, especially in high-risk groups. C. difficile mainly affects hospitalized people over 65 years old, who have been exposed earlier to antibiotics. The risk factors for C. difficile in these individuals include depletion of the protective intestinal flora by antibiotics and a low immune response to C. difficile due to both advanced age and medical comorbidities. The major outbreaks commonly occur in health care, as well as in long-term care institutions. However, CDI is not supervised in the Republic of Moldova.
 Conclusions. A system for reporting and monitoring of C. difficile infection needs to be implemented in order to promptly and efficiently manage hospital outbreaks.
Highlights
A NARRATIVE SYNTHESIS ON THE EPIDEMIOLOGY OF CLOSTRIDIOIDES DIFFICILE Introduction
Un studiu a prevalenței de moment a infecțiilor asociate asistenței medicale și consumul antimicrobienelor în spitalele din Republica Moldova a constatat că nu se efectuează testarea materiilor fecale pentru determinarea infecției cu C. difficile (ICD), astfel, lipsesc datele oficiale cu referire la incidența morbidității acestei infecții [8]
1. C. difficile este un agent patogen responsabil pentru colita infecțioasă severă, care duce la morbiditate și mortalitate alarmante la nivel mondial
Summary
A NARRATIVE SYNTHESIS ON THE EPIDEMIOLOGY OF CLOSTRIDIOIDES DIFFICILE Introduction. Clostridium difficile has been identified as the leading cause of antibiotic therapy-associated diarrhea and colitis, which has evolved from sporadic complications of antimicrobial therapy to severe, sometimes fatal events that have eventually become an endemic life-threatening issue among hospitalized and immunosuppressed patients worldwide. Clostridioides difficile este o bacterie sporulată, responsabilă de diareea infecțioasă și de colita pseudomembranoasă, cu o morbiditate și o mortalitate înaltă, în special la pacienții din grupul de risc. Factorii de risc pentru infecția cu C. difficile îi constituie epuizarea florei intestinale protectoare la antibiotice și răspunsul imun diminuat din cauza vârstei și a comorbidităților medicale.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
