Abstract
Cutaneous T-cell lymphoma is a heterogeneous group of malignancies including both indolent and aggressive forms, with an average 5-year disease-specific survival rate of 11-100%. Prognostic factors in cutaneous T-cell lymphoma according to the different subtypes are not clearly defined, however extracutaneous manifestation seems to predict a poor prognosis. Tonsil involvement was revealed as a cause of oropharyngeal complaints in two of our male patients, treated for histologically confirmed tumour stage of mycosis fungoides. In the first case urgent tracheostomy followed by radiotherapy, while in the other case systemic treatment resulted in complete remission of the tonsil involvement. Both patients were subsequently lost due to the progression of mycosis fungoides. Factors predicting an unfavourable prognosis included extracutaneous manifestation, late stage disease, age over 60 years, elevated lactate-dehydrogenase levels, and large cell transformation. With our cases we would like to shed light to the prognostic markers of mycosis fungoides, and to the rare tonsil involvement, which is potentially life-threatening and requires urgent intervention.
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