Abstract
The multiplicity of infection (MOI) is an important parameter for influenza A virus replication in animal cell culture. Depending on the respective question addressed in research or vaccine production, a range comprising several orders of magnitude is typically covered. Mathematical models, however, have paid little attention to the impact of MOI on virus replication dynamics so far. To overcome this limitation, we implemented kinetics that consider the time point of cell infection in an existing model of influenza A virus replication. We find that the extended model closely captures infection dynamics for MOI conditions ranging from 10-4 to more than one infectious virion per cell. Additionally, this model allows the reproduction of both the concentration of infectious virions and the total number of virus particles. Therefore, the extended model is well suited to predict process performance and to optimize influenza A virus production in cell cultures.
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