Abstract
Cell migration in a three-dimensional (3D) extracellular matrix (ECM) is one of the key biological processes. Yet many fundamental questions remain unanswered. In this chapter, we introduce a modeling framework for a 3D, element-based, multiscale cell migration model. This model takes into account the mechanosensing signaling pathway, cell morphological dynamics, and cell-ECM interactions. To integrate the mechanochemical dynamics, we developed an implicit integration method to calculate forces for the elements and a moving boundary reaction-diffusion solver. The model is partially tested for cell migration on a curved substrate. Further development is needed to couple the cell model with a mechanical ECM model. This model can be used to test hypotheses of cell-ECM interactions and cell migration in tissue environment.
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