Abstract

Recently, speech pattern analysis applications in building predictive telediagnosis and telemonitoring models for diagnosing Parkinson's disease (PD) have attracted many researchers. For this purpose, several datasets of voice samples exist; the UCI dataset named “Parkinson Speech Dataset with Multiple Types of Sound Recordings” has a variety of vocal tests, which include sustained vowels, words, numbers, and short sentences compiled from a set of speaking exercises for healthy and people with Parkinson's disease (PWP). Some researchers claim that summarizing the multiple recordings of each subject with the central tendency and dispersion metrics is an efficient strategy in building a predictive model for PD. However, they have overlooked the point that a PD patient may show more difficulty in pronouncing certain terms than the other terms. Thus, summarizing the vocal tests may lead into loss of valuable information. In order to address this issue, the classification setting must take what has been said into account. As a solution, we introduced a new framework that applies an independent classifier for each vocal test. The final classification result would be a majority vote from all of the classifiers. When our methodology comes with filter-based feature selection, it enhances classification accuracy up to 15%.

Highlights

  • Parkinson’s disease was first introduced in 1817 by Doctor James Parkinson as “shaking palsy” [1]

  • The results reveal that k-neural networks (NN) classifier performance is almost analogous to random guessing when it is used with LOSO cross validation technique

  • Results show that A-Multiple-Classifier with Feature Selection (MCFS) outperforms summarized leave-one-out (s-LOO)’s best result with overall accuracy of 77.50%, which is a 12.5% improvement and Matthew’s correlation coefficient score (MCC) of 0.5507

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Summary

Introduction

Parkinson’s disease was first introduced in 1817 by Doctor James Parkinson as “shaking palsy” [1]. It is the second common neurological disease coming afterwards Alzheimer and is mostly common among elders [2, 3]. PD is a kind of progressive disease in which an area of brain becomes damaged over the years. From one perspective, these signs and symptoms can be grouped into two major categories: motor symptoms and nonmotor symptoms. Motor symptoms are those that affect movement and muscles and nonmotor symptoms include neurobehavioral and cognitive problems, sleep problems, sensory problems, and autonomic neuropathy (dysautonomia) [4]

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