Abstract
Computational models have become essential in predicting medical device efficacy prior to clinical studies. To investigate the performance of a left-ventricular assist device (LVAD), a fully-coupled cardiac fluid-electromechanics finite element model was developed, incorporating electrical activation, passive and active myocardial mechanics, as well as blood hemodynamics solved simultaneously in an idealized biventricular geometry. Electrical activation was initiated using a simplified Purkinje network with one-way coupling to the surrounding myocardium. Phenomenological action potential and excitation-contraction equations were adapted to trigger myocardial contraction. Action potential propagation was formulated within a material frame to emulate gap junction-controlled propagation, such that the activation sequence was independent of myocardial deformation. Passive cardiac mechanics were governed by a transverse isotropic hyperelastic constitutive formulation. Blood velocity and pressure were determined by the incompressible Navier-Stokes formulations with a closed-loop Windkessel circuit governing the circulatory load. To investigate heart-LVAD interaction, we reduced the left ventricular (LV) contraction stress to mimic a failing heart, and inserted a LVAD cannula at the LV apex with continuous flow governing the outflow rate. A proportional controller was implemented to determine the pump motor voltage whilst maintaining pump motor speed. Following LVAD insertion, the model revealed a change in the LV pressure-volume loop shape from rectangular to triangular. At higher pump speeds, aortic ejection ceased and the LV decompressed to smaller end diastolic volumes. After multiple cycles, the LV cavity gradually collapsed along with a drop in pump motor current. The model was therefore able to predict ventricular collapse, indicating its utility for future development of control algorithms and pre-clinical testing of LVADs to avoid LV collapse in recipients.
Highlights
The optimal function of the heart relies on multiphysics phenomena, comprised of electrical activation, as well as myocardial contraction and blood hemodynamics
We describe the implementation of heart-left ventricular assist device (LVAD) interaction by introducing a failing dilated heart and adding a LVAD model to the standard framework
The model started from the end-diastolic volume (EDV) phase, where vortices from the previous filling phase still persist in both ventricles
Summary
The optimal function of the heart relies on multiphysics phenomena, comprised of electrical activation, as well as myocardial contraction and blood hemodynamics. Development of cardiac medical devices has to consider these multiphysics interactions during both pre-clinical and clinical studies. Multiphysics cardiac computational models can be a test-bed for early ideas to assess how therapeutic interventions could impact the diseased heart. This is especially beneficial to reduce the risk to patients with rare medical conditions, where the number of subjects that can be recruited for device clinical trials is limited. Results from computational simulations could be used to generate more plausible hypotheses for future testing; helping to reduce development and technology transfer costs and potential clinical adverse reactions
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.