A Multimode Model for Conventionally Fractionated Radiation Therapy and Stereotactic Body Radiotherapy

Abstract

Accurate radiobiological modeling is essential to the consistent dosimetric analysis and outcome comparison between conventionally fractionated radiation therapy (CFRT) that employs small daily doses (1.8-4 Gy) and stereotactic body radiotherapy (SBRT) that employs ablative doses (8-30 Gy/fraction). The linear quadratic (LQ) model gives a good description of the dose to the shoulder for CFRT but over predicts the potency and toxicity for SBRT. The multitarget model fits the empirical data well at high dose region but fails to produce the shoulder.