Abstract
We have developed Quantitative Human Physiology (QHP), an open source Windows‐based mathematical model of integrative human physiology containing over 3000 variables. QHP describes human physiology using whole‐body properties, organs, and multi‐organ systems. Users can view time‐dependent solutions and interactively alter parameters to investigate new hypotheses. All aspects of the model, including the mathematical equations describing the physiological processes have an XML open source, text‐readable description of the physiology. Model structure is based upon documented physiological responses within the peer‐reviewed literature. The model can be used to understand proposed physiological mechanisms and physiological interactions that may not be otherwise intuitively evident. Uses of this model include the analyses of renal control of blood pressure, the central role of the liver in creating and maintaining insulin resistance, and the mechanisms causing orthostatic hypotension in astronauts. Additionally the open source aspect of the modeling environment allows any investigator to add detailed descriptions of human physiology to test new concepts. QHP provides scientists a modeling environment to understand the complex interactions of integrative physiology. The model is freely available at http://physiology.umc.edu/themodelingworkshop. Supported by HL 51971 and NSF EPSCOR
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