Abstract
Background: COVID-19 is a disease produced by a viral infection peculiar to the SARS-CoV-2 and which produces an intense inflammatory response after the infectious process with participation of immune pathways, like IRF5, that could enhance post-infection actions. Thus, understanding the aspects of pathophysiological pathways for IRF5 involved in immunoinflammatory responses is essential to search for biomarkers that can help to identify early patients who would have the worst outcome. Methods and Findings: A comparative study between two groups of patients with cases of COVID-19 divided considering the number of days on which the patient had manifestations that led him to hospitalization (7 days). Blood samples were collected to evaluate IL-6 and DNA. Polymorphisms in IRF5 pathways genes (TLR7, IRF5, IL6, IFNA, IFNB1, IFNG) were genotyping by TaqMan® assay using Real-Time PCR (Applied Biosystems). The rs2069849 showed the G allele more frequently in a group that present less than seven days of symptoms, and the same SNP was correlated with highest serum levels of IL-6. Conclusions: Our results suggest that IL6 gene polymorphism, involved in the IRF5 pathway, can be associated with the worst patient’s outcome in COVID-19. The rs2069849 in the IL6 gene have been linked and could, in the future, be used as biomarker.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
