Abstract
Summary Objectives To investigate cerebral perfusion as a potential mechanism of exercise-related cognitive improvements and to further associate cognition and cerebral perfusion in Parkinson's disease. Equipment and methods Cerebral perfusion was measured continuously at rest and during a cognitive task using near-infrared spectroscopy before and after a multifaceted exercise program in thirteen individuals with Parkinson's disease. Results Cognitive function was not significantly impaired in our group of Parkinson's disease participants at baseline. Cerebral perfusion (69.91% ± 2.43) was significantly greater during cognitive testing than while resting (68.12% ± 2.42) (P ≤ 0.001). Our results are inconclusive with respect to the effect of exercise on cognitive dysfunction in PD.
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