Abstract
IntroductionThree histological variants (hyaline vascular, plasma cell, and mixed) and two clinical types (localized and multicentric) of Castleman's disease have been described. The risk of progression to lymphoma is higher in multicentric Castleman's disease and is associated with poorer outcomes and higher mortality rate. Multicentric Castleman's disease often requires systemic therapy. Complete resection of the involved node in localized Castleman's disease is curative, with no reported recurrences.Case presentationWe report a case of a 66-year-old female with systemic symptoms and bilateral cervical lymph nodes which were initially diagnosed as the hyaline vascular variant of Castleman's disease and two years later after the initial diagnosis she was confirmed to B cell lymphoma. Following the treatment with radiation therapy to the cervical area and combination chemotherapy complete response was achieved.ConclusionAlthough it has rarely been reported, the malignant potential of the Castleman's disease must be kept in mind.
Highlights
Three histological variants and two clinical types of Castleman’s disease have been described
Case presentation: We report a case of a 66-year-old female with systemic symptoms and bilateral cervical lymph nodes which were initially diagnosed as the hyaline vascular variant of Castleman’s disease and two years later after the initial diagnosis she was confirmed to B cell lymphoma
The hyaline vascular variant of Castleman’s disease (CD) is characterized by a marked increase of abnormal follicles with athrophic germinal centers which are poor in terms of follicular cells and rich
Summary
Castleman’s disease (CD) was firstly defined in 1956 as a mediastinal lymph node hyperplasia consisting of “regressed” germinal center and capillary “proliferation”. Localized CD is most often an isolated benign lymphoproliferative disorder and the vast majority of cases are of the hyaline vascular variant It is usually asymptomatic and is rarely associated with an increased risk of lymphoma [7]. We present a rare case of multicentric, hyaline vascular variant of Castleman’s disease that transformed to associated with B cell lymphoma. Case presentation We present a case of a 66-year-old Turkish female with the multicentric, hyaline vascular variant of CD that associated with diffuse large B cell lymphoma. She applied to our center in January 2006, with bilateral cervical masses which have persisted two years since the initial diagnosis and progressively growed. The patient is in complete remission with a follow-up of 2 years
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