A multicenter study to measure the validity of simple mucosal biopsy criteria predicting patients with ulcerative colitis ultimately requiring surgery

Abstract

tests analysis of variance, student's t-test, Mann-Whitney U test and Linear regression were used Results: Mean serum laminin levels were 281.0+ 110.1 ng/ml in UC patients and 2756-+ 106.7 ng/ml in CD patients signihcantly higher compared to healthy controls (192.0-+ 178 ng/ml) and the inflammatory controls (198.5 -+ 32.5 ng/ml) (P<0.O001). Mean serum collagen IV levels were 72.8 -+ 22.9 ng/ml in UC patients 71.0 -+ 18.2 in CD patients significantly lower compared to healthy controls (79.8-+ 12.2 ng/ml) and the inflammatory contmls (889 +_ 246 ng/ml) (P<0.O001) A strong corrdation between serum laminin, but not of collagen IV, and disease activity was found in both diseases. Serum laminin was positively correlated with CRP (r=0.46, P=O.02) and negatively with albumin (r-0.54, p = 0.006). Conversely, no correlation between serum collagen IV and CRP or albumin was bund No significant association between laminin or collagen IV and disease localization or disease type was tound. [BD patients with primary sclerosing eholangitis (7 cases) had significant higher collagen IV (105.9 35.9 ng/ml) but not different laminin levels (283 9 + 133 5 ng,/mD compared to patients without primary sderosing chohngitis. Conclusions Serum levels of laminni are increased whereas serum levels of collagen IV are decreased ta patients with inflammatory bowel disease. They may be useful surrogate markers for sustained inflammation and tissue remodeling.