A multi-center study of wet suction technique under endoscopic ultrasound for solid lesions

Abstract

Objective To compare the diagnostic values of different endoscopic ultrasound guided fine needle aspiration (EUS-FNA) biopsy methods (dry suction technique and wet suction technique)for solid tumors. Methods A total of 22 cases diagnosed as having digestive malignant tumors were enrolled, in each case endoscopic ultrasound (EUS) guided dry-FNA and wet-FNA were simultaneously carried out. Samples were taken respectively for cytologic and histopathologic examination. Then the quality of tissue specimens and diagnostic accuracy between the two groups were compared. Results The positive diagnostic rates of dry-FNA and wet-FNA in cytologic pathology were 27.27%(6/22)and 45.45%(10/22) without significant difference (P>0.05). The positive diagnostic rates of dry-FNA and wet-FNA in histopathology were 40.91%(9/22)and 72.73%(16/22, P<0.05). The cell count in wet-FNA was higher than that in dry-FNA(45.5±11.5 VS 26.0±9.5, P<0.05). The puncture tissue scores in wet-FNA was higher than that in dry-FNA (4.3±1.5 VS 2.9±1.4, P<0.05). In 22 cases, the combined diagnostic positive rates of cytologic and histopathologic examination in dry-FNA and wet-FNA were 45.45%(10/22)and 81.82%(18/22, P<0.05), which were significantly higher than those in separate cytologic or histologic examination (P<0.05). Conclusion Wet-FNA method is simple and easy to operate, which provides high quality samples and good diagnostic positive rate. It has the superior value to dry-FNA in the diagnosis of solid tumors. Key words: Pathology; EUS-FNA; Dry-FNA; Wet-FNA