Abstract
A Multicenter, Randomized, Double-Blinded, Comparative Study of Two Hyaluronic Acid Filler Products for the Correction of Nasolabial Folds
Highlights
The nasolabial fold (NLF) becomes prominent during the aging process mainly due to the volume loss of deep and superficial soft tissue and redistribution of fat compartments [14]
No serious adverse effects were observed during the entire follow-up period. Both hyaluronic acid (HA) filler products were found to be safe and effective for the correction of NLFs. The results of this spilt-face designed study confirm that YS24 is non-inferior to RP20 in correcting moderate to severe NLFs of Korean subjects
Injection of HA fillers gives its volume by drawing water and it is known to stimulate collagen and elastin leading to long-term correcting effect [8,9,10]
Summary
The nasolabial fold (NLF) becomes prominent during the aging process mainly due to the volume loss of deep and superficial soft tissue and redistribution of fat compartments [14]. Various filling materials are being used for volume restoration which is essential to correct the NLF [7]. Both effectiveness and safety must be guaranteed when choosing a filling material. Cross-linked hyaluronic acid (HA) gel is considered as a standard filling agent since it has exhibited unique and attractive properties [8]. HA fillers have been extensively used as a non-surgical, minimally invasive method to restore nasolabial folds in the past decades. Injecting hyaluronic acid (HA) filler has become the most frequently performed minimally invasive procedure for the correction of the nasolabial fold (NLF). Understanding the property of a specific filler product is important when using HA fillers for NLFs since they differ among individuals in shape and dynamics
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