Abstract
The original work in this paper is a multi-scale method (including micro scale, mesoscopic scale, macro scale and their coupling) for modeling degradation of bioresorbable polyesters and provides understanding to the process of degradation of biodegradable polymers. The result denotes the solution is reliable. As we know, there have no papers recently to implement three scales modeling and its coupling. There is a two-scale model of amorphous polyester degradation described by Han and Pan (Acta Biomaterialia 2011), our model accounts for effects of re-crystallization to explain the degradation process from three scales and takes into account of copolymers. From our model, the molecular weight distribution with time, chain number with time, degree of crystallinity with time, the evolution of polymer inner shape, weight loss with time (which is found from calculation that both oligomer diffusion and small molecules solution work to the weight loss) can be obtained from the calculation of the three scale model.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
