Abstract
BackgroundThis multi‐institutional retrospective study focused on the clinical outcome of carbon‐ion radiotherapy (C‐ion RT) for non‐squamous cell malignant tumors of the nasopharynx.MethodsThe Japan Carbon‐ion Radiation Oncology Study Group collected and analyzed data for 43 patients with non‐squamous cell malignant tumors of the nasopharynx treated with C‐ion RT at four institutions in Japan.ResultsTwenty‐nine patients had adenoid cystic carcinomas, seven had malignant melanomas, three had adenocarcinomas, two had mucoepidermoid carcinomas, and two had other pathologies. Twenty‐six of the 43 patients (61%) had T4 tumors. The most common dose‐fractionation schedule was 64 Gy (relative biological effectiveness) in 16 fractions. The median follow‐up period was 30 months. The 2‐year local control (LC) and overall survival (OS) rates were 88% and 84%, respectively. For late toxicity, one patient developed grade 4 optic nerve disorder and two developed grade 5 pharyngeal hemorrhage. Actual incidence of grade 3 or higher late adverse events was 19%, and included cranial nerve dysfunction, jaw bone necrosis, central nervous system necrosis, and ear inflammation.ConclusionsC‐ion RT provided good LC and OS rates with acceptable toxicity for treatment of non‐squamous cell malignant tumors of the nasopharynx.
Highlights
Nasopharyngeal carcinoma (NPC) is common in South and Southeast Asia, where the incidence is 25 to 50 per 100 000 people.[1]
The most common histologic type of NPC is poorly differentiated squamous cell carcinoma (SCC), which is different from other head and neck cancers.[2]
Non‐squamous cell malignant tumors of the nasopharynx such as adenoid cystic carcinoma, malignant melanoma, adenocarcinoma, and mucoepidermoid carcinoma are rare compared with SCC.[5]
Summary
Nasopharyngeal carcinoma (NPC) is common in South and Southeast Asia, where the incidence is 25 to 50 per 100 000 people.[1]. There has been increasing evidence of its efficacy and safety for head and neck malignant tumors.[12,13,14,15,16,17,18] to date, there are no reports of C‐ion RT for non‐squamous cell malignant tumors of the nasopharynx. Japan Carbon‐ion Radiation Oncology Study Group (J‐CROS) which consisted of all of four institutions performing C‐ion RT in Japan undertook a study to assess the efficacy and safety of C‐ion RT for non‐ squamous cell malignant tumors of the nasopharynx in a multi‐institutional retrospective analysis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
