Abstract
Cognitive dysfunction is associated with functional impairment of patients with Major Depressive Disorder (MDD). The goals were to explore the associated factors of cognitive impairment in MDD and to develop and validate a brief and culture-relevant questionnaire, the Taiwan Cognition Questionnaire (TCQ), among patients with MDD. This was a cross-sectional, multi-center observational study of MDD patients in Taiwan. Participants of Group 1 from 10 centers contributed to the validation of the TCQ by their response and sociodemographics. The participants of Group 2 from one center received an objective cognitive assessment for clarification of the relationship between the TCQ score and its associated factors. In Group 1, 493 participants were recruited. As for Group 2, an extra 100 participants were recruited. The global Cronbach’s alpha for the TCQ was 0.908. According to the coordinates of the ROC curve, 9/10 was the ideal cut-off point. With the criteria, the sensitivity/specificity of the TCQ was 0.610/0.689. The TCQ score was positively associated with a history of being admitted to acute psychiatric care and the severity of depression and negatively associated with objective cognitive measures. The TCQ provides a reliable, valid, and convenient measure of subjective cognitive dysfunction in patients with MDD.
Highlights
Major Depression Disorder (MDD) is a common and disabling mental disorder around the world
The second was the development and validation of a brief and culturerelevant questionnaire, the Taiwan Cognition Questionnaire (TCQ), which could be used as a domain-specific and objective measure of cognitive function in MDD
In Group 2, participants were assessed with objective measures to define the suitable cut-off points of TCQ for identifying cognitive dysfunction in MDD
Summary
Yung-Chieh Yen 1,2 , Nan-Ying Chiu 3,4 , Tzung-Jeng Hwang 5,6 , Tung-Ping Su 7,8,9,10,11 , Yen-Kuang Yang 12,13,14 , Cheng-Sheng Chen 15,16 , Cheng-Ta Li 17,18,19 , Kuan-Pin Su 19,20,21 , Te-Jen Lai 22,23 and Chia-Ming Chang 24,25, *. Study for the Development of the Taiwan Cognition Questionnaire (TCQ) in Major Depressive Disorder. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
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