A mucin-like peptide induces protection against Fasciola hepatica infection

Abstract

Event Abstract Back to Event A mucin-like peptide induces protection against Fasciola hepatica infection Teresa Freire1*, Veronica Noya1, Natalie Brossard1, Ernesto Rodriguez1, Daniel Mazal2, Patricia Berasaín3 and Carlos Carmona3 1 Facultad de Medicina, Inmunobiología, Uruguay 2 Hospital Pereyra Rossell, Anatomía Patológica, Uruguay 3 Facultad de Ciencias, Instituto de Higiene, Unidad de Biología Parasitaria, Uruguay Fasciola hepatica is a worldwide distributed helminth pathogen that causes great economic losses in sheep and cattle. The appearance of F. hepatica populations that are resistant to common flukicidal drugs, along with the fact that these drugs do not avoid the hepatic damage in animals, means that new methods of treatment are required. The future prospect for the development of anti-liver fluke vaccines is optimistic and given their consumer acceptability and environmental friendliness, offer the best way forward. Our group has recently identified a putative mucin-like protein, Fhmuc, expressed in the invasive newly excysted juvenile (NEJ). Mucins are highly O-Glycosylated proteins that are associated with evasion of immune response and adhesion of parasite and hence important for parasite survival in harmful host environment. Thus, this mucin might be a good vaccine candidate against fasciolosis In this work we present data regarding the immune response induced by the mucin-like peptide Fhmuc. We observed that Fhmuc has pro-inflammatory properties both in vitro and in vivo, leading to the production of high levels of pro-inflammatory cytokines. When tested in a model of fasciolosis in mice, Fhmuc has proven to protect from infection, especially when administrated together with dendritic cells. These results open new horizons in the development of vaccines against Fasciola hepatica infection. Acknowledgements Funded by Agencia Nacional de Investigación e Innovación, Uruguay Keywords: Vaccine, mucin, dendritic cell, Fasciola hepatica, fasciolosis Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Freire T, Noya V, Brossard N, Rodriguez E, Mazal D, Berasaín P and Carmona C (2013). A mucin-like peptide induces protection against Fasciola hepatica infection. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00734 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Teresa Freire, Facultad de Medicina, Inmunobiología, Montevideo, 11800, Uruguay, tfreire@fmed.edu.uy Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Teresa Freire Veronica Noya Natalie Brossard Ernesto Rodriguez Daniel Mazal Patricia Berasaín Carlos Carmona Google Teresa Freire Veronica Noya Natalie Brossard Ernesto Rodriguez Daniel Mazal Patricia Berasaín Carlos Carmona Google Scholar Teresa Freire Veronica Noya Natalie Brossard Ernesto Rodriguez Daniel Mazal Patricia Berasaín Carlos Carmona PubMed Teresa Freire Veronica Noya Natalie Brossard Ernesto Rodriguez Daniel Mazal Patricia Berasaín Carlos Carmona Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.