Abstract
We have previously demonstrated the severity of synovitis in patients with inter-critical gout did not correlate with serum urate levels (sUA). The aim of this sub-study was to determine if serum urate lowering therapy can improve this chronic synovitis.
Highlights
Clinical gout begins as an acute intermittent and intensely painful arthritis that can progress to a chronic, inflammatory, destructive condition
We have previously demonstrated that MRI is the best advanced imaging technique at demonstrating the synovial pannus that is present during inter-critical gout [14]
This was a single-center prospective pilot study performed at the University of South Florida (USF Health) in Tampa, FL. It was a sub-study of the parent study assessing the prevalence of synovial pannus and its correlation with serum urate levels in patients with inter-critical gout [15]
Summary
Clinical gout begins as an acute intermittent and intensely painful arthritis that can progress to a chronic, inflammatory, destructive condition. The initial episodes may last several days and are often followed by pain-free, inter-critical periods that may last months to years. Chronic gouty arthritis is manifested by shorter inter-critical periods, boney destructive changes and possible development of visible tophi. Advanced gout leads to chronic pain, decreased quality of life, and an increased global economic burden [1,2,3,4,5]. Epidemiologic data suggest that the prevalence of gout is increasing [6]. The obvious key to controlling the natural course of this serious disease is an efficacious therapy that treats the root cause
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