A movement orchestrated by DNA damage

Abstract

Cancer Doxorubicin is a commonly used therapeutic that kills cancer cells by inducing genotoxic stress. Harvey et al. found that treatment of cancer cells with clinically relevant doses of doxorubicin promoted the phosphorylation of the translation factor eIF2α, which, rather than inhibiting protein synthesis as might be expected, led to increased migration. Inhibiting eIF2α phosphorylation with a U.S. Food and Drug Administration–approved drug restricted doxorubicin-induced cell migration. Sci. Signal. 12 , eaaw6763 (2019).