Abstract

The relationship between radiation-induced DMA double-strand breakage (dsb) and cell killing for two mouse lymphoma lines was compared with that for hamster V79 cells. One of the lymphoma lines (STRij-4-2.2), which undergoes rapid interphase death (apoptosis) following cytotoxic insult, showed extreme sensitivity to gamma ray or DNA-associated iodine-125 decay-induced DNA dsb (7 ± 1 iodine-125 decays per lethal event). Surprisingly, the other lymphoma line (WEHI-22.1), which does not undergo rapid interphase death, was also much more sensitive to DNA dsb than were V79 cells (17 ± 1 versus 61 ± 2 decays per lethal event). Flow cytometric data suggested that both lymphoma lines may ultimately undergo rapid interphase death but the induction of this process in WEHI-22.1 may depend upon blockage in G2-phase. It is concluded that there are marked differences between the radiation responses of lymphoma and fibroblast lines.

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