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Abstract
The effects prenatally and postnatally of 50 ppm NaF in water on morphology of rat molars was studied. The control group (I) dams drank only distilled water prenatally and postnatally; Group II dams drank fluoridated water prenatally and postnatally, while Group III dams drank similar fluoridated water only postnatally. All dams ate a low-fluoride diet. Their offspring (375) were sacrificed when 19-days-old; and the right first mandibular molars sectioned and measured. Statistical analyses of measurements revealed that the overall sizes and shapes of molars were not significantly altered. Nevertheless, in female offspring of Group II, layers of enamel at bases of fissures were significantly thicker ( p = 0.01); likewise, a significant ( p < 0.01) inverse relation was observed between the thicknesses of enamel lining medial fissures and widths and depths of fissures. The bones and teeth of offspring of Groups II and III rats accumulated significantly ( p < 0.001) greater amounts of fluoride than Group I offspring.
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