Abstract
The transcriptional feedback loop that controls the fundamental daily rhythm of biological organisms has proven to be more intricate than expected. Now Lee et al . show that the fungus Neurospora joins the fruit fly and mouse in having two interlocked feedback loops at the core of the circadian clock. The clock component frequency has a positive effect on another clock component, white collar-1 and -2 levels, in addition to its previously described inhibitory effect on its own transcription. This extension of the two-loop pattern to a fungus indicates the generality of this organization. Lee, K., Loros, J.J., and Dunlap, J.C. (2000) Interconnected feedback loops in the Neurospora circadian system. Science 289 : 107-110. [Abstract] [Full Text]
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