Abstract
A sensitive electrochemical immunosensor based on a molybdenum disulfide (MoS2) and gold nanorods (AuNRs) composite was developed for the detection of microcystin-LR (MC-LR). The immunosensor was constructed by immobilizing MC-LR antibody on the MoS2/AuNRs nanocomposite modified gold electrode. Using a competitive immunoassay format, the coated MC-LR antibody competed for MC-LR antigen with added target MC-LR, forming an antibody-antigen immunocomplex. Subsequently, horseradish peroxidase-labeled anti-MC-LR antibody (HRP-Ab2) was captured and detected. Under optimal conditions, the immunosensor exhibited a linear response to MC-LR ranging from 0.01 to 20μgL−1 with a detection limit of 5ngL−1 at a signal to noise of 3. This electrochemical immunosensor showed good performance with high sensitivity, good stability, accepted reusability and promising applications in routine water quality monitoring for various toxins.
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