Abstract
CNDO/2 calculations were completed on various cogeners of the chloramphenicol molecule to study the potency of this antibiotic. Several mo indices correlated well with the biological activities. Little effect upon the stabilization of the radical intermediate was found. The substituents apparently alter significantly only the electrostatic interactions with the receptor.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have