Abstract
AbstractA simple, general and straightforward synthesis of novel spiro[oxindoline‐3, 4′‐isoxazolo[5, 4‐b]pyrazolo[4, 3‐e]pyridines] by one‐pot three‐component reaction of isatins, 5‐aminopyrazoles and 5‐aminoisoxazoles in water using p‐toluenesulfonic acid monohydrate (p‐TSA.H2O) as the catalyst is described. The notable advantages of the protocol are good to excellent yields, short reaction time, simple purification process involving no chromatographic technique, use of water as the solvent system, application of p‐TSA.H2O as cost‐effective catalyst, mild reaction conditions and operational simplicity that make the protocol highly attractive.
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