A molecular dynamics exploration of the binding of phosphatidylinositol-4,5-bisphosphate to transient receptor potential canonical 3

Abstract

Calcium signalling is an essential mechanism for regulating an array of processes in humans, including muscle contraction, nerve conductance, and fertilisation. Central to calcium signalling is a superfamily of calcium-permeable ion channels, the transient receptor potential (TRP) channels, which respond to a variety of signals to allow Ca2+ influx. One such TRP channel, the transient receptor potential canonical channel 3 (TRPC3), is activated by the lipid diacylglycerol (DAG) and positively modulated by phosphotidylinositol-4,5-bisphosphate (PIP2).