Abstract

G-quadruplexes (GQs) are of particular biological significance due to their widespread role in various biological processes such as transcription, translation, and replication. These guanine rich structures are energetically stable and fold into helices with several stacked guanine tetrads that can form up to four strands. Due to their abundance in the genome and their unique structural character, GQs have emerged as a new class of molecular targets for drug development and important biotechnological applications such as in the development of biosensors and biomaterials.

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