Abstract
We report a modular peptide that mimics the pro-angiogenic properties of vascular endothelial growth factor and the hydroxyapatite-binding ability of bone protein osteocalcin. It binds rapidly and efficiently to hydroxyapatite, and locally induces early pro-angiogenic activities, including endothelial cell proliferation and migration both when it exists in a soluble form and when it is immobilized on a hydroxyapatite biomaterial.
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