Abstract
A concise synthetic approach to construct [6,6,6]-tricyclic core, bearing 14-membered carbocyclic skeleton and oxygen at C13 of lophotoxin, has been described. This approach features a diastereoselective intermolecular Diels–Alder furan reaction and intramolecular Michael reaction. N-methylmaleimide was found to be critical for achieving the stable intermolecular Diels–Alder furan outcome.
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