Abstract
AbstractPurpose: The aim of this study was to incorporate the influence of the blinking effects on the post‐lens tear film (PoLTF) oxygen tension evolution in a model of a cornea. Indeed, the reservoir effect of the PoLTF has often been overlooked in the previous models. Here, both the oxygen tension and consumption profiles across the cornea are described over several cycles of blinking from the insertion of the lens to the reach of a steady‐oscillation state.Methods: A numerical model of the cornea was developed based on previous studies, the oxygen consumption of the cornea being described by the Monod kinetics model [1]. The temporal variations of the oxygen tension in the PoLTF were added using the model of Fatt and Hill [2]. The oxygen tension and consumption at different times were calculated, while varying the fractional reservoir volume (FRV) not replenished by the blink, 0.82 being the FRV giving results closest to reality according to Fatt and Hill.Results: As expected, the higher the value of FRV, the lower the oxygen tension and oxygen consumption were across the cornea. At steady state, the model showed an average corneal oxygen consumption diminution of 5.7% between two blinks for a FRV equal to 0.82. This diminution increases with the value of FRV.Conclusions: This simple numerical model provides a theoretical support and contributes to the better understanding of the oxygen uptake of the cornea while wearing a lens. However, assuming that the oxygen tension of the PoLTF is not influenced by the oxygen consumption inside the cornea may constitute a limitation.References.1. Compañ V, Aguilella‐Arzo M, Weissman BA. Corneal Equilibrium Flux as a Function of Corneal Surface Oxygen Tension. Optom Vis Sci. 2017;94(6):672–679. PMID: 28514247.2. Fatt I, Hill RM. Oxygen tension under a contact lens during blinking‐‐a comparison of theory and experimental observation. Am J Optom Arch Am Acad Optom. 1970;47(1):50–5. PMID: 5262987.
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