Abstract
Vascular-platelet and plasma hemostasis was studied in dogs after blood loss (40–45 ml/kg body weight) followed by hypervolemic (60–65 ml/kg body weight) transfusion of homologous (from three donors) plasma enriched with platelets and leukocytes. After a brief phase of hypercoagulation, hypocoagulation was discovered in all the experimental dogs, accompanied by a reduction in the platelet count and in the intensity of platelet aggregation, lengthening of the bleeding time, a decrease in the resistance of the capillary wall, a decrease in the plasma fibrinogen concentration and activity of factor XIII, and an increase in the fibrinolytic activity of the blood. The results are evidence of the development of an acute syndrome of disseminated intravascular blood clotting.
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