A model of Defence Mechanical Drug Delivery System (DmechD) and the drug release efficacy

Abstract

The slow progress in the effectiveness of treatment of diseases has stimulated treatment approaches from various disciplines in order to deliver therapeutics to the target tissues. From this, new ideas on controlling the efficacy of drugs have been generated. The aim of controlled-drug delivery system is to directly deliver drugs to the affected sites. Controlled-drug delivery with good targeting, precise amount and exact speed of release are crucial for drug effects. Therefore, in this study, the model of drug delivery system using PIC 16F873A and PIC 16F84A microcontrollers was developed and the effectiveness of releasing drug and distance at open area and with thicknesses of 0.85 m obstacle wall were determined. The development of Defence Mechanical Drug Delivery System (DmechD) model was divided into three parts that are 1) a capsule containing drug release system using DC geared motor, 2) Transmitter and Receiver Circuit using PIC 16F873A and PIC 16F84A microcontroller with IC Max 232, and a serial port RS 232, and 3) the interface control panel using visual basic 6.0 software to give the command control from work station. At the open area, the signal can be transmitted and received until 8 meters while only 6 meters at area with obstacle. At 6-meter distance, the releasing of drug was 4.72% delayed at obstacle area as compared to the open area. In this paper, a model for a controlled drug delivery capsule mechanical device was successfully developed and the drug release speed using PIC 16F873A and PIC 16F84A microcontrollers and DC geared motor was also discussed.