Abstract
A probability model is developed for transmission of a centric-fusion translocation from one generation to the next, giving probability distributions for gametes, zygotes, and liveborn children of different types. The biological assumptions of the model and different alternatives to them are thoroughly discussed. Models of this type form an important part of a theory of population genetics for inherited structural chromosome rearrangements. The treatment is devoted to human populations only. With reference to two segregation analyses carried out by means of the model, the types of insights in the biological mechanisms obtainable by using such a model are demonstrated.
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