Abstract
A model is presented, which is based on the idea that the chromosome damage induced by Mitomycin C results directly from repair or misrepair of DNA molecules responsible for the linear continuity of the chromosomes. Testing the model with human cells confirms the prediction that exchanges with complete joining occur between chromosome regions containing homologous, repetitive DNA. Most probably incomplete exchanges involve homologous, but unique DNA sequences. — Prerequisites determining the MC-induced aberration patterns are the distribution of the chemical due to compartmentalization, the somatic pairing of chromosomes, and the occurrence of repeated or unique DNA sequences. — The scoring of different classes of MC-induced chromatid aberrations (attenuation, constriction, gap, break) in alcohol/acetic acid-fixed chromosome has a limited value.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
