Abstract

The movement of certain pathogens, such as Listeria monocytogenes, is commonly believed to be driven by actin polymerization. By hijacking the actin machinery of the host cell, these pathogens can move in the cytoplasm with a speed in the order of 0.1 μm/s. Several microscopic or macroscopic models have been proposed to account for the force generation by actin polymerization, however, a theoretical explanation for the rich trajectories traced out by the pathogens, including circles, winding S curves, translating figure eights, and serpentine shapes etc., is still lacking.

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