Abstract
A new theoretical model, termed the “bridging sequence model”, is presented to describe the mechanism of transcriptional control of eukaryote genes. According to the model, short regions of RNA exist which are highly complementary to the RNA sequence immediately surrounding a splice junction, and which are coded for elsewhere in the genome. Their function is to determine the site of splicing and to modulate the RNA processing of the pre-gene transcript. Computer-assisted sequence analysis of the genome of the virus SV40 has confirmed the predicted existence of these bridging sequences for both of the virus' early genes. Available experimental data supports the interpretation that the identified bridging sequences are required for RNA processing or control of RNA transcription.
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