Abstract
In this paper we present a model for osmotically induced weight transients in the isolated perfused rabbit heart. The model consists of a set of lumped parameter, first-order, ordinary differential equations describing the solute and volume flow across the capillary and cell membranes. The differential equations describing the model have been solved by using a Hewlett-Packard Model HP9830 computer. The results, in terms of weight changes, solute, and solvent flows are given in graphical form. This paper has indicated the importance of diffusion, solvent drag, elastic factors, capillary sieving, interstitial pressure changes, lymph flow, transcellular (myocytal) transport, all as a function of time and related these to simultaneous weight changes. The parameters used for our model are values which have all been experimentally obtained in the isolated perfused rabbit heart. Results are presented using two small, water-soluble test molecules, inulin and NaCl, since they elicit different tissue responses to osmotic perturbation. For an inulin transient the main loss of weight occurs in the extracellular compartment. When NaCl is used as the test solute the main loss of weight is from the heart muscle cells. While complete in itself this paper is the starting point for two associated articles on factors important in the estimation of capillary permeability and reflection coefficients.
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