Abstract
A Mn-based metal-organic framework Mn-CPP was synthesized and showed excellent chemodynamic therapy (CDT) effect. DOX was selected and loaded into Mn-CPP obtaining DOX@Mn-CPP to improve the therapeutic properties. DOX@Mn-CPP exhibited better drug release behaviors in the tumor environment than that in normal environment. Besides, the material displayed good biocompatibility to L929 cells and significant effect of lethality on 4T1 cells and Hela cells. The successful fabrication of DOX@Mn-CPP provided the potential application for the combination therapy of chemodynamic therapy and chemotherapy.
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