A mixed-integer optimization approach for homogeneous magnet design

Abstract

Magnetic resonance imaging (MRI) is a powerful diagnostic tool that has become the imaging modality of choice for soft-tissue visualization in radiation therapy. Emerging technologies aim to integrate MRI with a medical linear accelerator to form novel cancer therapy systems (MR-linac), but the design of these systems to date relies on heuristic procedures. This paper develops an exact, optimization-based approach for magnet design that 1) incorporates the most accurate physics calculations to date, 2) determines precisely the relative spatial location, size, and current magnitude of the magnetic coils, 3) guarantees field homogeneity inside the imaging volume, 4) produces configurations that satisfy, for the first time, small-footprint feasibility constraints required for MR-linacs. Our approach leverages modern mixed-integer programming (MIP), enabling significant flexibility in magnet design generation, e.g., controlling the number of coils and enforcing symmetry between magnet poles. Our numerical results demonstrate the superiority of our method versus current mainstream methods.