A Mixed Comparisons of Different Intensities and Types of Physical Exercise in Patients With Diseases Related to Oxidative Stress: A Systematic Review and Network Meta-Analysis

Zhenghui Lu,Yining Xu,Yang Song,István Bíró,Yaodong Gu

doi:10.3389/fphys.2021.700055

Zhenghui Lu, Yining Xu + Show 3 more

Open Access

https://doi.org/10.3389/fphys.2021.700055

Copy DOI

Abstract

The balance of oxidative and antioxidant systems is of great importance to the human body. Physical exercise, as one of the ways to improve physical health, seems to modulate this balance. However, different intensities and types of physical exercise have other effects on the treatment of unhealthy people. To understand the impact of exercise training on the oxidative and antioxidant systems of adults with oxidative stress-related disorders, a network meta-analysis was used to compare the mixed effects of different intensities and types of exercise training. This systematic review included all eligible RCTs from PubMed, Medline, Cochrane Library, and CINAHL. Eleven of the studies met the inclusion criteria (at study completion, n = 666 participants). Seven studies reported that the level of MDA decreased significantly after exercise (p < 0.05), and 3 studies reported that the level of SOD increased significantly after exercise (p < 0.05). In conclusion, long-term high-intensity aerobic training and Tai Chi or Yoga can effectively improve oxidative stress in unhealthy people. In addition, different types of diseases on the effect of exercise intervention seems to be other, diabetes and chronic kidney patients using moderate-intensity aerobic training or Tai chi and Yoga effect are better; Moderate-intensity aerobic training had a better impact on OS improvement in patients with irritable bowel syndrome and severe depression. However, more research is needed to determine the effects of different levels and types of physical activity on oxidative stress in unhealthy populations.Systematic Review Registration: PROSPERO identifier: CRD42021242025. https://www.crd.york.ac.uk/prospero/.

Highlights

Oxidative stress (OS) would occur when the oxygen metabolism by-products were produced and accumulated and eventually beyond oxidation-resist ability (Sies, 1991, 1997; Newsholme et al, 2016; Pizzino et al, 2017; Powers et al, 2020)
The results show that for unhealthy people, the means to reduce the level of MDA from the best to the worst are high-intensity aerobic training (HIAT), moderate-intensity aerobic training (MIAT), Tai Chi or Yoga, Blank and lowintensity aerobic training (LIAT)
The results show that for unhealthy people, the means to improve the level of SOD from the best to the worst are Tai Chi or Yoga, MIAT, Blank and high intensity aerobic mixed resistance training (HIART)

Summary

Introduction

Oxidative stress (OS) would occur when the oxygen metabolism by-products were produced and accumulated and eventually beyond oxidation-resist ability (Sies, 1991, 1997; Newsholme et al, 2016; Pizzino et al, 2017; Powers et al, 2020). Mixed Interventions for Oxidant Stress is an essential factor in myocardial infarction (Yan et al, 2018), which may lead to liver damage (Rigamonti et al, 2003) and be a potential risk factor of diabetes and cardiovascular disease (Locatelli et al, 2003; Newsholme et al, 2016), and related to the pathogenesis of hypertension (Briones and Touyz, 2010). When there is excessive production of active species, especially reactive oxygen species (ROS) and active nitrogen species (RNS), it will cause severe damage (Newsholme et al, 2016), for example, the destruction of cell structure, lipids, proteins and genetic material (Islam, 2017)

Objectives

Methods

Findings

Discussion

Conclusion